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nordicbioscience膠原蛋白形成生物標(biāo)志物

更新時(shí)間：2020-11-24 點(diǎn)擊次數(shù)：2206

nordicbioscience膠原蛋白形成生物標(biāo)志物

Assay name	Assay description	Volume required (uL)
PRO-C1	Internal epitope in the N-terminal pro-peptide of type I collagen	50
PRO-C2	Released N-terminal pro-peptide of type II collagen	50
PRO-C3	Released N-terminal pro-peptide of type III collagen	50
PC3X	Cross-linked N-terminal pro-peptide of type III collagen	50
iP3NP	Internal epitope in the N-terminal pro-peptide of type III collagen	50
PRO-C4	Internal epitope in the 7S domain of type IV collagen	50
PRO-C5	Released C-terminal pro-peptide of type V collagen	50
PRO-C6	C-terminal of released C5 domain of type VI collagen α3 chain (endotrophin)	50
PRO-C8	C-terminal of type VIII collagen	50
PRO-C10	C-terminal of type X	50
PRO-C11	Released N-terminal pro-peptide of type XI collagen	50
PRO-C16	C-terminal of Type XVI collagen	50
PRO-C18	N-terminal type XVIII collagen	50
PRO-C18L	N-terminal of the type XVIII collagen medium and long isoforms	50
PRO-C19	C-terminal of type XIX collagen	50
PRO-C23	C-terminal of type XXIII collagen	50
PRO-C28	C-terminal of type XXVIII collagen	50

Collagen degradation biomarkers

Assay name	Assay description	Volume required (uL)
C1M	Neo-epitope of MMP-2,9,13 mediated degradation of type I collagen	50
C2M	Neo-epitope of MMP mediated degradation of type II collagen	80
T2CM	Neo-epitope of MMP-1 and -13 mediated degradation of type II collagen	50
C3M	Neo-epitope of MMP-9 mediated degradation of type III collagen	50
urine C3M	Neo-epitope of MMP-9 mediated degradation of type III collagen	50
C3A	Neo-epitope of ADAMTS-4,5 mediated degradation of type III collagen	50
C3C	Neo-epitope of cathepsin-B,L,S mediated degradation of type III collagen	50
C4M	Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 1 chain	50
C4Ma3	Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 3 chain	50
TUM	MMP-9 mediated release of tumstatin from type IV collagen alpha 3 chain	50
urine C4M	Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 1 chain	50
C4G	Neo-epitope of granzyme B mediated degradation of type IV collagen	50
C5M	Neo-epitope of MMP-2,9 mediated degradation of type V collagen	50
C6M	Neo-epitope of MMP-2 mediated degradation of type VI collagen	50
C6Ma3	Neo-epitope of MMP-9 mediated degradation of type VI collagen	50
C7M	Neo-epitope of type MMP-13 mediated decradation of type VII collagen	50
C10C	Neo-epitope of cathepsin-K mediated decradation of type X collagen	50
Col10NC	Neo-epitope of the NC domain of type X collagen	50
CTX-I	Neo-epitope of cathepsin mediated degradation of type I collagen	50
CTX-II (Urine)	Neo-epitope of MMP mediated degradation of type II collagen	100
CTX-III	Cross-linked type III collagen C-terminal telopeptide	50

Elastin based biomarkers

Assay name

Assay description

Volume required (uL)

EL-CG

Neo-epitope of caghepsin G mediated degradation of elastin

ELM

Neo-epitope ('441) of MMP-9,12 mediated degradation of elastin

ELM12

Neo-epitope ('552) of MMP-9,12 mediated degradation of elastin

ELM7

Neo-epitope of MMP-7 mediated degradation of elastin

EL-NE

Neo-epitope of neutrophil elastase mediated degradation of elastin

ELP-3

Neo-epitope of proteinase-3 mediated degradation of elastin

Wound healing biomarkers

Assay name	Assay description	Volume required (uL)
PRO-FIB	Neo-epitope of thrombin mediated degradation of fibrinogen	50
X-FIB	Neo-epitope of plasmin mediated degradation of cross-linked fibrin (sandwich assay)	80
FXIIIAP	Neo-epitope of thrombin mediated degradation of transglutaminase FXIII	50
vWF-A	Neo-epitope of ADAMTS13 mediated degradation of von willebrand factor	50
vWF-N	Released N-terminal pro-peptide of von willebrand factor	50
F1.2/F2	Neo-epitope of Fxa/Fva mediated degradation of prothrombin	50
F1	Neo-epitope of thrombin mediated degradation of prothrombin	50
T-FIB	Neo-epitope of plasmin mediated degradation of fibrin	50

Extracellular matrix associated biomarkers

Assay name	Assay description	Volume required (uL)
a-SMA	Acetylated N-terminal of alpha-smooth muscle actin	50
BGM	Neo-epitope of MMP-9,12 mediated degradation of biglycan	50
DCN-CS	Cathepsin S mediated decorin degradation	50
HSP47-C	C-terminal of heat shock protein-47	50
LAM	Neo-epitope of MMP-9 mediated degradation of laminin alpha 5 chain	50
LG1M	Neo-epitope of MMP-9 mediated degradation of laminin gamma 1 chain	50
MIM	Neo-epitope of MMP-9,12 mediated degradation of mimecan	50
NIC	Neo-epitope of cathepsin-S mediated degradation of nidogen	50
SPARC-M	Neo-epitope of MMP mediated degracation of SPARC	50
TIM	Neo-epiotpe of MMP-12 mediated degradation of titin (Cardiac isoform)	50
TIM-2	Specific fragment of MMP-12-mediated degradation of titin (Muscle isoform)	50
VCANM	Neo-epitope of MMP-8,12 mediated degradation of versican	50
VICM	Neo- epitope of MMP-2, 8 and trypsin mediated degradation of citrullinated vimentin	50
ARGS	N-terminal epitope of Aggrecanase mediated degradation of aggrecan	50
FBN-C	C-terminal of fibronectin	50
CPa9-HNE	Neo-epitope fo human neutrophil elastase (HNE) mediated degradatib if calprotectin	50
PROM	Neo-epitope of MMP-1 and -13 mediated degradation of prolargin	50
uPerla	Neo-epiotpe of ADAMTS mediated degradation of perlecan	50
exAGNxI	Neo-epitope of aggrenase mediated aggrecan	50
exFFGV	Neo-epitope of MMP mediated aggrecan	50
BREM	Brevican degraded by MMPs	50
BREV-A	Neo-epitope of ADAMTS-4 mediated degradation of brevican	50
n-BREV	N-terminal of brevican	50
TAU-A	Neo-epitope of ADAM-10 mediated degradation of TAU	50
TAU-C	Neo-epitope of caspase-3 mediated degradation of TAU	50
exMMP3	Activated MMP-3	50
acCAT-K	Activated Cathepsin K	50
acMMP-9	Activated MMP-9	50
acMMP-13	N-terminal of active MMP-13	50
acADAMTS4	N-terminal of active ADAMTS-4	50
acADAMTS5	N-terminal of active ADAMTS-5	50
COMP-N	N-terminal of COMP	50
SPARC-C	C-terminal of SPARC	50
AGR-N	N-terminal of agrin	50
FBN-EDA	Neo-epitope of MMP-8 mediated degradation of cellular fibronectin (EDA domain)	50
FMODM	Fibromodulin degraded by MMP-12	50

Other biomarkers

Assay name	Assay description	Volume required (uL)
GDF-8	Myostatin (growth/differentiation factor 8)	150
IL-6	Interleukin-6	250
FMODM	Fibromodulin degraded by MMP-12	50
Ostase BAP	Bone-specific Alkaline Phosphatase ELISA	100
PIIANP	Type IIA Collagen N-Propeptide (PIIANP) ELISA	10
C-P-Tau (181P)	Phosphorylated Tau (P181)	50
C-β-Amyloid (1-42)	Amyloid Beta 1-42	50
HCG	Chorionic Gonadotropin (pregnancy test)	10
PTH, intact	Parathyroid hormone	50
S-Free T4	thyroxine	15
S-Testosterone	testosterone	20
S-Total T3	Total triiodothyronine	30
S-TSH	thyroid stimulating hormone	50
Total PINP	N-terminal pro-peptide of type I collagen	20
Anti-CCP	Anti-citrullinated protein antibodies	15
Anti-HCV	Antibodies to hepatitis C virus	50
HBsAg II	Hepatitis B surface antigen	50
HIV combi PT	HIV-1 P24 antigen, antibodies against HIV-1 and HIV-2	40
HIV-Ag	HIV-1 P24 antigen group M and O	50
Insulin	Insulin	20
S-Albumin	Albumin	2
S-ALAT	Alanine transaminase	25
S-ASAT	Aspartate transaminase	25
S-Bilirubin	Total billirubin	14.3
S-Calcium	Serum calcium	16
S-Cholesterol	Serum cholesterol	4
S-Creatinine	Serum creatinine	24
S-GGT	Gamma-glutamyltransferase	10
S-Glucose	Glucose	3.4
S-protein	Total serum protein	17.5
S-Urea	Serum urea	7
S-HDL Cholesterol	Serum HDL cholesterol	5
S-LDL Cholesterol	Serum LDL cholesterol	5
Urine Calcium	Urine calcium	16
Urine Creatinine	Urine Creatinine	24
Urine Phosphat	Urine Phosphat	8
S-Phosphat	Serum phosphat	8
S-Magnesium	Serum magnesium	12
S-Lipase	Serum lipase	3
S-Amylase	Serum amylase	16
S-LDH	Serum LDH	14
S-CO2	Serum CO2	6
ELF		65

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